Introduction: The problem was addressed in terms of the need to verify whether the application of neurodidactic strategies supported by digital tools would have the potential to personalize learning and increase students' academic performance by responding effectively to individual cognitive processes. Objectives: In this sense, the objective of the study was to analyze how the application of neurodidactics, supported by digital tools, can strengthen the personalization of learning. Methodology: The research was conducted under the pragmatic paradigm, ideal for the use of mixed methods, integrating quantitative and qualitative data through a survey validated with SPSS, inductive-deductive analysis, and a quasi-experimental design with pre- and post-tests for a particular group. It was also exploratory, descriptive, explanatory, field-based, and documentary research. Theoretical methods such as inductive-deductive and analytical-synthetic were used, as well as empirical methods such as surveys, whose statistical reliability was verified using Cronbach's alpha coefficient (0.980 for students). The population consisted of 202 students, with a sample of 59 tenth-grade students from Upper General Basic Education. In the second quarter, a traditional methodology was used, and in the third quarter, digital tools with a neurodidactic approach were applied. Results: The results show a significant improvement in the students' academic performance, from an average of 8.1219 in the pretest to 9.1602 in the posttest, a difference validated by the student’s t-test. Conclusions: It is concluded that integrating neurodidactics with digital tools promotes attention, memory, and motivation, personalizing learning and positively transforming teaching practices, orienting them toward inclusive and effective environments. General area of study: Education. Specific area of study: Digital environment. Type of study: Original article.