Introduction. The growing global demand for poultry production historically drove the use of Antibiotic Growth Promoters (AGPs). However, regulatory restrictions, such as the ban on these drugs in livestock, have led to public health problems caused by antimicrobial resistance and residues in food. This has spurred the search for alternative feed additives to improve poultry performance. Probiotics, prebiotics, and symbiotic have emerged as alternatives to AGPs. These are live microorganisms that act on pathogens, non-digestible substrates that stimulate microorganisms in the gut, and synergistic combinations of probiotics and prebiotics, respectively. Objective. To analyze, through a systematic literature review conducted under the PRISMA declaration, the effect of supplementation with probiotics, prebiotics and symbiotic on live weight, daily weight gain, and feed conversion in poultry. Methodology. A systematic search was conducted in PubMed, Scopus, Web of Science, and ScienceDirect using MeSH terms. Fifty-six studies (50 productive) published between 2021 and 2026, evaluating approximately 18,544+ birds, were included. Results. Probiotics (Bacillus subtilis strain) increased live weight by 7.4 to 8.1% (p<0.05). Prebiotics (MOS, FOS, β-glucans) improved feed conversion by 3–11%. Symbiotic showed the greatest effectiveness in daily weight gain (100% of studies with positive results). The optimal dose identified was 2 × 10⁹ CFU/kg for probiotics and 0.1–0.5% for prebiotics. Conclusion. Probiotics, prebiotics, and symbiotic are effective alternatives to antibiotic growth promoters, with Bacillus subtilis PS-216 and commercial symbiotic being the most consistent options for improving production parameters in poultry. General Area of Study: Veterinary medicine. Specific area of study: Animal Nutrition. Type of study: Systematic bibliographic review.